C60 Fullerenes

The Research

The Story of Dani's search for the ultimate delivery system...

The Search

Since their discovery in 1985, C60 Buckminsterfullerenes have taken the scientific & medical research world by storm.

Countless studies showed that fullerenes (C60) exhibit incredible potential in biology and medicine, including UV and radioprotection, antiviral, antioxidant activities, allergic response inhibitions, immune stimulating and anti-tumour effects, gene delivery, and even hair-growing activity. C60 suspended in pure organic oil is opening doors to amazing health benefits that scientists and researchers have been  astounded by.

All of the incredible benefits of C60 combined with all the skin healing benefits of Organic Argan oil, and all the amazing health benefits of Organic Black Seed & Hemp Seed oil!

The Research

THIS is where old world ingredients meets new world chemistry, bringing together elements that will change how we look at health and healing.

Here are a few of the best research papers and scientific studies done on C60 Fullerenes:

This first paper is one of the most important, as it is the “story”, of several lab rats who were fed C60 Fullerenes to try and find it’s “Toxicity” levels… and they refused to die.          …For YEARS.

The_prolongation_of_the_lifespan_of_rats_by_repeat

Impacts of fullerene C60 and virgin olive oil on cadmium-induced genotoxicity in rats.

Currently, cadmium is considered to be one of the major environmental pollutants. Environmentally, cadmium is released in various forms e.g. oxide, chloride and sulphide. The aim of the present study was to examine the genotoxic impact of fullerene nanoparticles C60 (C60) and virgin olive oil (VOO) on cadmium chloride (CdCl2)-induced genotoxicity in rats. …. Surprisingly, C60 and VOO significantly attenuated the genotoxic effects caused by CdCl2 in livers and kidneys. In bone marrow, in addition to a reduction in the chromosomal number, several chromosomal aberrations were caused by CdCl2. These chromosomal alterations were also reversed by C60 and VOO. In conclusion, molecular and cytogenetic studies showed that C60 and VOO exhibit anti-genotoxic agents against CdCl2-induced genotoxicity in rats.

https://www.ncbi.nlm.nih.gov/pubmed/29499533

Biological Safety of LipoFullerene composed of Squalane and

Fullerene-C60 upon Mutagenesis, Photocytotoxicity,

and Permeability into the Human Skin Tissue

 
….C60 dissolved in squalane may not give any significant biological toxic effects such as photocyto-
toxicity, bacterial reverse mutagenicity, and permeability into the human skin.
 
 

Clinical evaluation of fullerene-C60 dissolved in squalane for anti-wrinkle cosmetics.

The wrinkle and skin-surface roughness features were calculated and statistically analyzed. Subsequently, trans-epidermal water loss (TEWL), moisture levels of the stratum corneum, and visco-elasticity (suppleness: RO and elasticity: R7) were measured on cheeks by instrumental analysis. LF-SQ cream enhanced the skin moisture and the anti-wrinkle formation. LF-SQ cream that was applied on a face twice daily was not effective at 4th week, but significantly more effective than the placebo at 8th week (p < 0.05) without severe side effects.

https://www.ncbi.nlm.nih.gov/pubmed/21137794

Fullerene Nanomaterials Inhibit the Allergic Response

…fullerenes are capable of inhibiting MC and PBB allergic responses in vitro and anaphylaxis in vivo and suggests these molecules have previously unrecognized antiallergic properties. Fullerenes may represent a new way to control diseases largely influenced by these cells including type I hypersensitivity (anaphylaxis, hay fever, etc) (11), asthma (56), arthritis (57), multiple sclerosis (58), and other autoimmune diseases (59).

http://www.jimmunol.org/content/179/1/665.long

Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue.

UVA-caused corneum scaling and disruption of epidermis layer were detected by scanning electron microscopy. Breakdown of collagen type I/IV, DNA strand cleavage and pycnosis/karyorrhexis were observed in vertical cross-sections of UVA-irradiated skin models visualized with fluorescent immunostain or Hoechst 33342 stain. These skin damages were scarcely repressed by liposome alone, but appreciably repressed by Lpsm-Flln of 250 ppm, containing 0.75 ppm of C60-equivalent to a 1/3300-weight amount vs. the whole liposome.

https://www.ncbi.nlm.nih.gov/pubmed/20036139

Inhibition of sebum production and Propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: Potential as a therapeutic reagent for acne

 …It was also found that fullerenol has inhibitory activity against P. acnes lipase. These results suggest that fullerenol could be a beneficial skin care reagent for controlling acne vulgaris by suppressing sebum in the inflammatory response and by reducing P. acnes lipase activity.
(PDF) Inhibition of sebum production and Propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: Potential as a therapeutic reagent for acne.
 
 

Improvement of acne vulgaris by topical fullerene application: unique impact on skin care

Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging

 
  

Scalp care and Hair Growth

it became clear that hair growth rate became 16% faster by as early as after six months. From this result, it was confirmed that fullerene could increase hair growth rate. This was believed to be caused by protecting the cells around the hair follicle from the active oxygen.

http://www.vc60.com/en/tech/effect/hairgrowth.html

Fullerene nanomaterials potentiate hair growth

Hair loss is a common symptom resulting from a wide range of disease processes and can lead to stress in affected individuals. The purpose of this study was to examine the effect of fullerene nanomaterials on hair growth…. paralleled by a significant increase in the number of hair follicles in fullerene-treated mice as compared with those mice treated with vehicle only. The fullerenes also increased hair growth in human skin sections maintained in culture. These studies have wide-ranging implications for those conditions leading to hair loss, including alopeciachemotherapy, and reactions to various chemicals.

https://www.sciencedirect.com/science/article/pii/S1549963408001512

Anti-inflammatory effect of fullerene C60 in a mice model of atopic dermatitis.

CONCLUSIONS: We suppose that nC60 treatment shifts immune response from Th2 to Th1 and restores to some extent the function of the skin barrier. This approach can be a good alternative to the treatment of allergic and other inflammatory diseases.

https://www.ncbi.nlm.nih.gov/pubmed/26810232

Defensive Effects of Fullerene-C60 Dissolved in Squalane Against the 2,4-Nonadienal-Induced Cell Injury in Human Skin Keratinocytes HaCaT and Wrinkle Formation in 3D-Human Skin Tissue Model

he scanning electron microscopy demonstrated that NDA caused wrinkles and abnormal scales on keratinocytes of 3D-human skin tissue model, and structural homogeneity of the interstratum was broken, any of which were, however, markedly suppressed with LF-SQ. Squalane alone exhibited defensive effect against the skin tissue injury to some extent, but which was inferior to LF-SQ. LF-SQ might effectively capture and scavenge lipid radicals generated inside the cell membrane, because squalane acts as a lipophilic carrier of C60. C60 dissolved in squalane can be expected to serve as a cosmeceutical ingredient for anti-wrinkle formation.
Defensive Effects of Fullerene-C60… (PDF Download Available).

https://www.researchgate.net/publication/44627828_Defensive_Effects_of_Fullerene-C60_Dissolved_in_Squalane_Against_the_24-Nonadienal-Induced_Cell_Injury_in_Human_Skin_Keratinocytes_HaCaT_and_Wrinkle_Formation_in_3D-Human_Skin_Tissue_Model?enrichId=rgreq-9306ca07687fce0a93f536db7c9978ec-XXX&enrichSource=Y292ZXJQYWdlOzQ0NjI3ODI4O0FTOjE2MDMzOTYwMTY2NjA0OEAxNDE1MjM5MzQ4NDI1&el=1_x_3&_esc=publicationCoverPdf [

 PRISTINE C60 FULLERENES INHIBIT THE RATE OF TUMOR GROWTH

AND METASTASIS

 

 CARDIOVASCULAR EFFECTS OF FULLERENE DERIVATIVES:

A REVIEW OF CURRENT EVIDENCE

 

 

The polyhydroxylated fullerene derivative C60 (OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction

 
 
 

Fullerene-based antioxidants and neurodegenerative disorders

fullerenes-help-familial-als

 

Toxicity of pristine versus functionalized fullerenes: Mechanisms of cell damage and the role of oxidative stress

 
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